Photolysis and cytotoxicity of the potentially toxic composition of daylily flower: colchicine

The photolysis of colchicine under ultraviolet and visible light irradiation was studied by (UV) scanning HPLC-MS. photoproduct proposed the cytotoxicity change before after investigated. Results showed that both could effectively degrade into deacetamido-lumicolchicine. process conformed to first-order kinetics, in which a high degradation rate (K = 0.5862 h− 1) observed when dissolved ethanol irradiated UV light. Cell viability cell cycle studies proved treatment weaken effectively. Colchicine inhibited division BRL 3 A cells G2/M phase with an IC50 value 0.48 µg/mL, while toxic effect be reduced significantly 2.1 µg/mL exposed irradiation. are beneficial toxicity elimination processing daylily flower food industry, can also provide photochemistry reference for colchicine-related studies.